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Illumina

| 🗖 nosplit | ↑ parent "DNA sequencing company" | words: 182 | descendant words: 454 | descendants: 1
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The by far dominating DNA sequencing company of the late 2000's and 2010's due to having the smallest cost per base pair.
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Illumina actually bought their 2010's dominating technology from a Cambridge company called Solexa.
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To understand how Illumina's technology works basically, watch this video: Video 155. "Illumina Sequencing by Synthesis by Illumina (2016)".
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Video 155. Illumina Sequencing by Synthesis by Illumina (2016) Source.
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The key innovation of this method is the bridge amplification step, which produces a large amount of identical DNA strands: Figure 61. "Illustration of the bridge amplification step of Illumina's DNA sequencing.".
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Figure 61. Illustration of the bridge amplification step of Illumina's DNA sequencing. Source.
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This step is genius because sequencing is basically a noise to signal problem, as you are trying to observe individual tiny nucleotides mixed with billions of other tiny nucleotides.
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With bridge amplification, we group some of the nucleotides together, and multiply the signal millions of times for that part of the DNA.
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Ancestors

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