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Man-made virus!
TODO: if we had cheap de novo DNA synthesis, how hard would it be to bootstrap a virus culture from that?
Is it easy to transfect a cell with the synthesized DNA, and get it to generate full infectious viral particles?
If so, then de novo DNA synthesis would be very similar to 3D printed guns:
It might already be possible to order dissimulated sequences online:
Video 7. 3D Printed Guns Are Easy To Make And Impossible To Stop by VICE News (2018) Source.