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Find the most interesting research topic that no one is researching

Some cases:

Marie Curie according to Video 10. "Marie Curie section of The Mystery of Matter episode 2" at youtu.be/wbuDmY5gpXQ?t=2041 she specifically avoided more generic X-ray research, and went instead for radioactivity

Bibliography:

academia.stackexchange.com/questions/145290/how-to-choose-a-proper-research-topic-potential-and-or-having-no-strong-competit

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